Symptoms and Signs: Symptoms and Signs Gastrointestinal symptoms and disturbance of the fluid and electrolyte balances may be evident. Amoxicillin crystalluria, in some cases leading to renal failure, has been observed (see Precautions).
Treatment: GI symptoms may be treated symptomatically, with attention to the water/electrolyte balance.
Co-amoxiclav can be removed from the circulation by haemodialysis.
Children (additional statement): A prospective study of 51 paediatric patients at a poison control centre suggested that overdosages of less than 250 mg/kg of amoxicillin are not associated with significant clinical symptoms and do not require gastric emptying.
Drug abuse and dependence: Drug dependency, addiction and recreational abuse have not been reported as a problem with this compound.